2 Department of Health Sciences, Clinical Microbiology Unit, 'Magna Graecia' University, Catanzaro, Italy. Similarly, a reinforcement of the network to keep in care migrants who initiated treatment or deserve clinical monitoring is necessary. Affiliations 1 Department of Medical and Surgical Sciences, Infectious and Tropical Diseases Unit, 'Magna Graecia' University, Catanzaro, Italy. Our results demonstrated that both screening and vaccination strategies for HBV need to be improved in migrant populations. Among those who were HBsAg positive, 73.9% were still in care at month 6 of follow-up, and only 43.3% were in care one year later. At a follow-up evaluation of the latter group, only 56.9% had by then been vaccinated, 17.6% had the vaccination course ongoing, and 17.1% had not started their vaccination course. After our intervention, 23 (6.9%) were diagnosed as HBsAg carriers, whereas 204 (61.8%) were potentially eligible for vaccination. At the first evaluation, only 30% of them had already received screening for HBV. 5 Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy. 4 Science of Health Department Magna Graecia University Catanzaro Italy. 2Researcher, Business Economics, Department of Clinical and Experimental Medicine, Magna Graecia University, Catanzaro, Italy. 3 Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Università degli Studi di Genova Genoa Italy. We evaluated 330 migrants who came to our centre between August 2015 and October 2018, and who were residing in seven different centres for refugees and asylum seekers. Affiliations 1Associate Professor, Business Economics, Department of Clinical and Experimental Medicine, Magna Graecia University, Catanzaro, Italy. We therefore conducted an analysis to evaluate the efficacy and outcome of the pathways of care (from screening to treatment) for HBV in a population of migrants. Unfortunately, screening and vaccination in this population can be challenging for several reasons. Italian guidelines recommend that all migrants be screened, vaccinated and treated for HBV, as required. Although Italy is considered a low prevalence setting for HBV infection, following significant migration in recent years there has been an increase in the occurrence of the disease. All rights reserved.Chronic hepatitis B virus (HBV) infection is a major health problem worldwide. This lipid-lowering effect was associated with significant reductions of biomarkers used for detecting oxidative vascular damage, suggesting a multi-action enhanced potential for BPF in patients on statin therapy.īergamot polyphenolic fraction Cardiometabolic risk Hyperlipidemia Rosuvastatin. The cholesterol lowering effect was accompanied by reductions of malondialdehyde, oxyLDL receptor LOX-1 and phosphoPKB, which are all biomarkers of oxidative vascular damage, in peripheral polymorphonuclear cells.Īddition of BPF to rosuvastatin significantly enhanced rosuvastatin-induced effect on serum lipemic profile compared to rosuvastatin alone. We are talking about a medium-sized institution of higher education, where about 10,000 people can complete a course each year. Patients were randomly assigned to a control group receiving placebo (n=15), two groups receiving orally administered rosuvastatin (10 and 20mg/daily for 30 days n=16 for each group), a group receiving BPF alone orally (1000 mg/daily for 30 days n=15) and a group receiving BPF (1000 mg/daily given orally) plus rosuvastatin (10mg/daily for 30 days n=15).īoth doses of rosuvastatin and BPF reduced total cholesterol, LDL-C, the LDL-C/HDL-C ratio and urinary mevalonate in hyperlipidemic patients, compared to control group. The aim of the present study is to investigate the occurrence of an enhanced effect of bergamot-derived polyphenolic fraction (BPF) on rosuvastatin-induced hypolipidemic and vasoprotective response in patients with mixed hyperlipidemia.Ī prospective, open-label, parallel group, placebo-controlled study on 77 patients with elevated serum LDL-C and triglycerides was designed. We hypothesize that the use of natural bergamot-derived polyphenols may allow patients undergoing statin treatment to reduce effective doses while achieving target lipid values. Besides the well-known efficacy of such compounds in both preventing and treating cardiometabolic disorders, some patients experience statin-induced side effects. Statins are the most commonly prescribed drugs to reduce cardiometabolic risk.
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